Studies have found "multi-change" immune cells or help to develop new crown vaccines
Xinhua News Agency Sydney August 24 (Reporter Hao Yalin) A new study of Australia’s research team found that organizational resident memory T cells (TRM cells) have different molecular characteristics and behaviors in different historical environments of human body, this discovery may have Assist in developing a new generation of new crown vaccines acting on the lung tissue.
TRM cells are immunocytes that are only in human tissues, and this cell has been found to fight viruses against viruses in this cell. The research team led by the Australian "Peter Dordi Infection and Immunization Research" reveals the barrier officials (such as skin) to the environment with solid organs such as the liver, and found that TRM cells resident in the historical environment These cells exert the ways of immune effects.
In different human tissues, TRM cells will quickly adapted to the surrounding molecules and proteins as changing dragons, and exhibit different functions and persistence.
Related papers have been published in the UK "Natural · Immunology" journal. The study found that there is a protein called conversion growth factor-β in the skin to inhibit TRM cells to be activated without necessarily, to avoid human immune system attack itself.
But TRM cells in the skin will "attack" when they encounter truly threats, and can last long.
There is no similar "mechanism" involved in the liver to inhibit TRM cells, so TRM cells can form "a huge army" to fight infection.
However, due to the shorter half-life of TRM cells in the liver, it may not be possible to "fight".
The researchers say that TRM cells have unique molecular characteristics and behaviors in specific tissues, which will help to develop T cell-based effective vaccines and immunotherapy, such as induced TRM cells in lung tissues, which can produce flu viruses. The respiratory virus such as new crown viruses is effective T cell immunity, and infects infection in positions that may be in contact with pathogens to cope with future infections that may occur in the future.
(Editor: Su Tongxiang, Yang Mu) Sharing let more people see.